2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-D1426
    Di-12-ANEPPQ 217176-86-8 98%
    Di-12-ANEPPQ is a fast-responding membrane potential dye. Di-12-ANEPPQ, the lipophilic dye, shows cell-specific loading and Golgi-like staining patterns with minimal background fluorescence in the slices of neocortex and hippocampus.
    Di-12-ANEPPQ
  • HY-D1439
    RH 795 172807-13-5 98%
    RH 795 is a lipophilic potentiometric styryl fluorescent dye (Ex/Em = 530 nm/712 nm). RH 795 stains the cell membranes of sensory cells and nerve fibers in living cells that maintain membrane potential, while it shows weak staining effect on supporting cells. RH 795 supports in vivo and in vitro confocal microscopy imaging of intact living inner ear cells and neuronal components. RH 795 can be used in studies related to hearing loss.
    RH 795
  • HY-D1528
    MTSEA-Fluorescein 1356019-48-1 98%
    MTSEA-Fluorescein is a fluorescent probe that can be used for ion channel research.
    MTSEA-Fluorescein
  • HY-D1536
    Glycine cresol red 77031-64-2 98%
    Glycine cresol red is a complexometric indicator. Glycine cresol red forms coloured complexes with Al3+, Ga3+ and In3+ ions in aqueous solutions. Glycine cresol red can been used for the spectrophotometric determination of inorganic ions. Glycine cresol red can be used as a stain in neurohistology.
    Glycine cresol red
  • HY-D1672
    TMR Biocytin 749247-49-2 98%
    TMR Biocytin is a polar tracer used in the research of cell-cell and cell-liposome fusions, as well as membrane permeability and cellular uptake during pinocytosis. TMR Biocytin can be detected using streptavidin, and is an effective neuronal tracer in live tissue (Ex=544 nm, Em=571 nm).
    TMR Biocytin
  • HY-D1704
    Bodipy TMR-X muscimol 849464-08-0 99.79%
    Bodipy TMR-X muscimol is a Bodipy labeled Muscimol (HY-N2313) (Ex=543 nm, Em=572 nm). Muscimol is a GABAA agonist. Bodipy TMR-X muscimol can be used for imaging the spread of reversible brain inactivations.
    Bodipy TMR-X muscimol
  • HY-D2260
    hMSCs-Neu perchlorate 2320522-38-9 98%
    hMSCs-Neu perchlorate (Compound 4) is a fluorescent probe that converts hMSCs into neurons in the presence of fibroblast growth factor (FGF). hMSCs-Neu perchlorate may have important applications in neuropathology and neurodegeneration research.
    hMSCs-Neu perchlorate
  • HY-D2266
    FluoBar1 98%
    FluoBar1 is an imaging fluorescence probe modified by a barbiturate ligand with fluorescent coumarin. FluoBar1 can monitor L-type voltage-gated calcium channels (LTCC) in living cells in real time for the study of neurological diseases .
    FluoBar1
  • HY-D2343
    PB0822 98%
    PB0822 can be used for in vivo PET imaging when labeled with [18F]fluoride. [18F]PB0822 is a PET radioligand. [18F]PB0822 has a cLogP value of 1.54, which is a good predictive index for BBB penetration. [18F]PB0822 can be used for Alzheimer’s Disease research.
    PB0822
  • HY-D2844
    FITC-PEG400-FA 98%
    FITC-PEG400-FA is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG400-FA can be used for fluorescent labeling and imaging.
    FITC-PEG400-FA
  • HY-D2962
    CAQ 98%
    CAQ is a near-infrared fluorescent probe based on a curcumin scaffold (Ex/Em = 565/635). CAQ exhibits high affinity for Aβ1-42 aggregates (Kd = 78.89 nM) and excellent selectivity toward common biomolecules. CAQ’s emission wavelength shows significant solvent dependence. CAQ, by incorporating intramolecular rotation donors and quinoline functional groups, can be used for the specific detection and imaging of Aβ aggregates in Alzheimer's disease.
    CAQ
  • HY-D2963
    R-MA-SLM
    R-MA-SLM is an Aβ-targeted and blood-brain barrier-permeable ratiometric H2O2-responsive fluorescent probe. When excited at 490 nm, the fluorescence intensity of the R-MA-SLM gradually decreases at 574 nm, while the emission intensity gradually increases at 661 nm. R-MA-SLM can detect and exhibits a ratiometric response to Aβ-induced endogenous H2O2. R-MA-SLM can be used in the research of Alzheimer's disease.
    R-MA-SLM
  • HY-D2967
    Golgi-NO
    Golgi-NO is a Golgi-targeted fluorescent probe for nitric oxide (NO) (Ex/Em: 560 nm/589 nm). Golgi-NO exhibits excellent selectivity for various potential interfering substances. Golgi-NO can be used to study the function of NO within the Golgi apparatus in disease models such as Alzheimer's disease (AD).
    Golgi-NO
  • HY-D2970
    Golgi-P 98%
    Golgi-P is a near-infrared Golgi-targeted fluorescent probe specifically used for the detection of Golgi polarity in living cells and living tissues. Golgi-P exhibits a significant polarity-dependent spectral behavior, with its emission wavelength shifting redward with polarity (Ex/Em: 700 nm/780-825 nm). Golgi-P achieves near-infrared fluorescence imaging directly in the brain tissue of depressed mice. Golgi-P combines polarity sensing with Golgi-targeting functionality, providing a new tool for the molecular diagnosis of depression.
    Golgi-P
  • HY-D2971
    NCIC-VIS 2781892-92-8 98%
    NCIC-VIS is a lysosome-targeted, viscosity-sensitive two-photon near-infrared fluorescent probe. NCIC-VIS has a rigid structure that can restrict molecular torsion, thereby increasing the fluorescence quantum yield and two-photon absorption cross-section. NCIC-VIS enables real-time imaging of the autophagy process in cells.
    NCIC-VIS
  • HY-D3171
    AD-BChE/HClO 98%
    AD-BChE/HClO is a dual-target two-photon fluorescent probe. AD-BChE/HClO can release 4-methylumbelliferone via butyrylcholinesterase-mediated hydrolysis of the ester bond at position 7, as well as hypochlorous acid-mediated thiocarbonyl oxidation. AD-BChE/HClO enables two-photon imaging in nerve cells and mouse brain tissues via tail vein injection. AD-BChE/HClO can be used for the research of Alzheimer's disease.
    AD-BChE/HClO
  • HY-D3179
    CDg13 1451048-96-6 98%
    CDg13 is a fluorescent probe that specifically detects living neural stem/progenitor cells. CDg13 localizes to the endoplasmic reticulum via its dihexyl moiety, with no interaction with endoplasmic reticulum biomolecules. CDg13 undergoes selective efflux by active ABCG2 transporters, with increased intracellular accumulation following ABCG2 inhibition or knockdown. CDg13 isolates and enriches self-renewable neural stem/progenitor cells from embryonic mouse brain tissue, stains neural stem/progenitor cells brightly, and sorts ABCG2low cell populations from heterogeneous populations. (Ex/Em = 520/553 nm)
    CDg13
  • HY-D3180
    CDr20 1201643-01-7 98%
    CDr20 is a fluorescent chemical probe capable of crossing the blood-brain barrier. CDr20 undergoes glucuronidation catalyzed by the UDP-glucuronosyltransferase Ugt1a7c, which triggers a fluorescence turn-on response. CDr20 enables visualization of live microglial cells. CDr20 can be used for research on Alzheimer's disease, stroke, and autism.
    CDr20
  • HY-D3207
    DHUCu-1 3037311-41-1 98%
    DHUCu-1 is a lysosome-targeted NIR divalent copper ion probe with high water solubility. DHUCu-1 serves as a tool for investigating the physiological functions of Cu2+ and related diseases, such as Menke syndrome, Wilson's disease, and Alzheimer's disease.
    DHUCu-1
  • HY-D3215
    Lyso-Cu(II) 1491152-19-2 98%
    Lyso-Cu (II) is a lysosome-targeted divalent copper ion probe. Lyso-Cu (II) is applicable to the research of Wilson's disease, Menkes disease and Alzheimer's disease.
    Lyso-Cu(II)
Cat. No. Product Name / Synonyms Application Reactivity